Similac Advance vs Pro Advance
Parenting Review

Similac Advance vs Pro Advance – 3 Major Differences

Is there a major difference between Similac Advance vs Pro Advance? This is a big question every parent who is considering bottle-feeding their baby asks. 

Which is a valid question. When it comes to parenting, there is rarely a manual for parents to follow, especially new parents.

So, when you ask such questions rather than using guesswork, you stand a better chance of understanding parenthood and everything regarding the health of your newborn. 

While most health practitioners recommend breastfeeding compared to formula feeding, some factors might lead you to consider formula feeding. 

Still, parents who opt to bottle feed their baby do their best to ensure their babies get the best nutrition close to breastfeeding if not all the nutritional benefits of breastfeeding. 

Similac Advance and Similac Pro Advance are popular breastmilk replacement formulas to cross the mind of many parents.

With both formulas receiving favorable reviews, some parents find it hard to decide which of these formulas is ideal for their baby.

Here’s everything you need to know to make an informed decision.

Editorial post: How Long Does It Take For Baby To Adjust To Formula

1. Similac Advance vs Pro Advance

Similac Advance vs Pro Advance

Similac Advance and Similac Pro Advance are popular brands of formula fit for infants who do not have a problem with cow’s milk.

Available in liquid form and classical powder form, both formulas are products of the Similac brand, which belongs to Abbot laboratories. 

These infant formulas have been designed to match mother’s breast milk closely.

They maintain close as possible all the intrinsic benefits of breastfeeding a baby, hence the popularity.

Similac Advance

Similac advance contains Similacs unique OptiGRO blend. This” nutritionally complete” milk-based formula has the following notable features:

  • Optigro blend, which includes DHA, Lutein, and Vitamin E
  • It has nutrients and vitamins vital for brain and eye development
  • No human growth hormones

Similac Pro Advance

This “closest formula to breast milk” has an exclusive blend of vitamins and nutrients with the inclusion of the 2’FL HMO.

These human milk oligosaccharides (HMO) are prebiotic components found in breast milk. 

Similac Pro Advance has this ingredient, though, in chemical form, that supports the baby’s immune system similar to those of a breastfed baby.


  • Optigro blend, DHA, Lutein and Vitamin E
  • 2’FL HMO
  • Non-GMO ingredients
  • No human growth hormones

2. Difference Between Similac Advance And Pro Advance

Similac advance and Similac Pro advance are fundamentally almost the same.

The ingredients components in both formulas are practically identical. However, there are slight differences and few ingredients that set them apart.

The significant and notable difference is that Similac Pro advance has the 2’FL HMO prebiotic found in breastmilk. 

Another slight difference between these two formulas is that Similac Advance sources of ingredients are from Genetically Modified Organisms (GMO).

In contrast, the ingredients used in Similac Pro Advance are GMO-free. 

The origins of Pro Advance formula ingredients are from naturally occurring animal products.

It’s important to know that GMO products are safe for human consumption and do not pose any harm to babies. 

The difference in price between these two formulas is up for debate, depending on the dealer.

Similac Pro Advance price may be a little bit higher from some sellers than the Similac Advance. Other stores might be the vice versa but at a minimal fee. 

3. Is Similac Pro Advance Better Than Similac Advance?

Similac Advance vs Pro Advance

Both formulas are very similar and quite effective in the overall health and wellbeing of your baby.

Some research on the effectiveness of Pro Advance versus the Similac Advance found that there were no evident differences in effects.

However, the fact that Pro Advance is non-GMO and contains the prebiotic 2’FL HMO found in breastmilk gives this formula an upper edge for some parents. 

The difference between Similac Advance vs Pro Advance is slightly minimal. Both formulas are a perfect choice for lactose-tolerant infants.

Both formulas are a solid choice for bottle-fed babies as well as supplementing breastfeeding.

However, it’s essential to consult your baby’s pediatrician or a healthcare provider to ask for their insights and recommendations on what’s best for your baby’s health. 

Frequently Asked Questions

Can I Switch My Baby From Similac Pro Advance to Similac Advance?

It’s possible to switch from Similac pro advance to Similac advance or vice versa. However, you might need additional guidance from your child’s doctor. 

Considering that both formulas have almost identical ingredients, the switch is possible though you might expect a few issues at first, depending on your baby.

For example, the change might cause tummy troubles, change in poop colour, diarrhoea or even reflux. 

Also, if you decide on making the switch, it’s essential to heed the specific standard procedures unless your pediatrician advises you to make the change immediately.

For instance, start by mixing ¾ of the pro advance with ¼  of Similac advance.

Then, gradually increase the ratio until you are only feeding the Similac Advance. 

Some babies may not get accustomed to the change immediately.

Therefore, it’s best to give it a few feedings. Still, it’s best to pick one and stick to it instead of constantly making the switch. 

Can You Mix Similac Advance and Pro Advance?

Considering that both formulas are of the same brand, it’s okay to mix Similac advance with pro advance as long as your baby accepts it.

For some infants, combining both formulas even provides a bit more balanced benefits. 

 Most importantly, you have to talk to your child’s pediatrician and heed some standard mixing instructions.

What Temperature Should Similac Formulas Be?

The perfect temperature for the formula should range equally or slightly less to body temperature. 96 degrees Fahrenheit ( 36 degrees Celsius ).

While it may be impractical to use a thermometer to test the temperature, the wrist method has proved helpful. 

First and foremost, it’s best to avoid the warming of formula. Still, if the only option at stake is feeding the baby warmed formula, do not microwave it.

Microwaving baby formula causes uneven hot spots in the bottle that may burn your baby.

The best alternative is setting the formula filled bottle in a bowl of water. Also, hold the bottle under running warm water and rotate it around all the sides.

Or, you can use a standardized bottle warmer. 

After warming the bottle, drop a few dribbles on the inside of your wrist to ensure it’s not too hot.

How Long Should I Keep Formula After Preparing it?

After mixing powdered formula, you have to use it within 24 hours.

Still, if you don’t feed it to your baby within 2 hours, refrigerate the bottle and use it within the 24-hour frame.

For the ready-to-feed and liquid concentrated formulas, use them within 48-72 hours after opening. Also, once opened, you have to store it in the fridge until the next feeding. 

Refrigerating prepared or opened formula protects bacteria from growing. Still, it’s best not to freeze the formula.

Dispose of the remaining powdered formula after the 24 hours time frame.

What Is Similac Pro Advance Good For?

As mentioned, the Similac Pro Advance has the 2’FL HMO that provides bottle-fed babies with complete nutrition necessary for strengthening an infant’s immune system.

Similar to breastfed babies. Also, the Optigro Blend contributes to the growth of a baby’s brain and eye development. 

How Long Does It Take For a Baby to Adjust To Formula Change?

For most babies, It takes 7-10 days to adjust to the new formula completely.

We can’t put the finger on the exact duration since all babies are likely to react differently to the recent change.

For some, though in rare cases,  you might expect an immediate response on the first day. 

Still, don’t panic if your baby doesn’t adjust to the new formula immediately or even if they experience some adverse reactions during the change.

Instead, give them enough time before they get accustomed to the new formula.

Still, don’t wait too long to ascertain that your baby isn’t responding well to the new formula.

You might consider seeking help from your child’s pediatrician if there is no improvement after the second week. 

How Do You Prepare a Bottle of Powdered Similac Advance Formula?

As long as you follow the appropriate guidelines, preparing Similac baby formula is a walk in the park.

However, to ensure your baby receives all the necessary nutrition, you must prepare the formula correctly.

To begin with, ensure your hands and all the utensils are clean. If possible, it’s best to sterilize the bottle and nipples.

Next, boil clean and fresh tap water for a few minutes, preferably not less than two minutes.

Overboiling the water might heighten the concentration of specific impurities. Let the water cool at room temperature for an utmost of 30 minutes.

Pour the necessary amount of water into the baby bottle. Then pour the powdered formula into the bottle using the provided scoop.

One scoop of powder is sufficient for 30 millilitres of water. Return the dry scoop to the can. 

Put the cap on the bottle and shake it until it completely dissolves.

And again, drop a few dribbles on the inside of your wrist to temperature.

If it’s lukewarm, feed your baby instantly. Or keep it in the refrigerator immediately. 

Can I Feed a Similac Formula While Still Breastfeeding My Baby?

Absolutely yes.

Feeding formula while concurrently breastfeeding, also referred to as supplementing, is perfectly safe. It’s a matter of preference or, in specific scenarios, doctor recommended.

Still, at times, it’s the best available solution for moms and babies.

However, if supplementing isn’t due to medical reasons, health care providers recommend breastfeeding exclusively for at least one month before starting with the formula.  

Is Similac Advance Good For Babies Who Constipate?

Yes. Similac Advance has proved to help babies have soft stool.

Hard stool to pass is one of the most prevalent signs of constipation for babies.

Similac advance has dietary fibre and galactooligosaccharides (GOS) that help babies to have soft stools.

GOS is a type of oligosaccharides found in breastmilk that plays the same purpose. 

Related Post: How To Use Spectra Breast Pump

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Iesha Mullah

Iesha is a loving mother of 2 beautiful children. She's an active parent who enjoys indoor and outdoor adventures with her family. Her mission is to share practical and realistic parenting advice to help the parenting community becoming stronger.

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