Similac Advance vs Pro Advance
Parenting Review

Similac Advance vs Pro Advance – 3 Major Differences

Is there a major difference between Similac Advance vs Pro Advance? This is a big question every parent who is considering bottle-feeding their baby asks. 

Which is a valid question. When it comes to parenting, there is rarely a manual for parents to follow, especially new parents.

So, when you ask such questions rather than using guesswork, you stand a better chance of understanding parenthood and everything regarding the health of your newborn. 

While most health practitioners recommend breastfeeding compared to formula feeding, some factors might lead you to consider formula feeding. 

Still, parents who opt to bottle feed their baby do their best to ensure their babies get the best nutrition close to breastfeeding if not all the nutritional benefits of breastfeeding. 

Similac Advance and Similac Pro Advance are popular breastmilk replacement formulas to cross the mind of many parents.

With both formulas receiving favorable reviews, some parents find it hard to decide which of these formulas is ideal for their baby.

Here’s everything you need to know to make an informed decision.

Editorial post: How Long Does It Take For Baby To Adjust To Formula

1. Similac Advance vs Pro Advance

Similac Advance and Similac Pro Advance are popular brands of formula fit for infants who do not have a problem with cow’s milk.

Available in liquid form and classical powder form, both formulas are products of the Similac brand, which belongs to Abbot laboratories. 

These infant formulas have been designed to match mother’s breast milk closely.

They maintain close as possible all the intrinsic benefits of breastfeeding a baby, hence the popularity.

Similac Advance

Similac advance contains Similacs unique OptiGRO blend. This” nutritionally complete” milk-based formula has the following notable features:

  • Optigro blend, which includes DHA, Lutein, and Vitamin E
  • It has nutrients and vitamins vital for brain and eye development
  • No human growth hormones

Similac Pro Advance

This “closest formula to breast milk” has an exclusive blend of vitamins and nutrients with the inclusion of the 2’FL HMO.

These human milk oligosaccharides (HMO) are prebiotic components found in breast milk. 

Similac Pro Advance has this ingredient, though, in chemical form, that supports the baby’s immune system similar to those of a breastfed baby.


  • Optigro blend, DHA, Lutein and Vitamin E
  • 2’FL HMO
  • Non-GMO ingredients
  • No human growth hormones

2. Difference Between Similac Advance And Pro Advance

Similac advance and Similac Pro advance are fundamentally almost the same.

The ingredients components in both formulas are practically identical. However, there are slight differences and few ingredients that set them apart.

The significant and notable difference is that Similac Pro advance has the 2’FL HMO prebiotic found in breastmilk. 

Another slight difference between these two formulas is that Similac Advance sources of ingredients are from Genetically Modified Organisms (GMO).

In contrast, the ingredients used in Similac Pro Advance are GMO-free. 

The origins of Pro Advance formula ingredients are from naturally occurring animal products.

It’s important to know that GMO products are safe for human consumption and do not pose any harm to babies. 

The difference in price between these two formulas is up for debate, depending on the dealer.

Similac Pro Advance price may be a little bit higher from some sellers than the Similac Advance. Other stores might be the vice versa but at a minimal fee. 

3. Is Similac Pro Advance Better Than Similac Advance?

Both formulas are very similar and quite effective in the overall health and wellbeing of your baby.

Some research on the effectiveness of Pro Advance versus the Similac Advance found that there were no evident differences in effects.

However, the fact that Pro Advance is non-GMO and contains the prebiotic 2’FL HMO found in breastmilk gives this formula an upper edge for some parents. 

The difference between Similac Advance vs Pro Advance is slightly minimal. Both formulas are a perfect choice for lactose-tolerant infants.

Both formulas are a solid choice for bottle-fed babies as well as supplementing breastfeeding.

However, it’s essential to consult your baby’s pediatrician or a healthcare provider to ask for their insights and recommendations on what’s best for your baby’s health. 

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